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1 гидроксилазы
[греч. hydro(genium) — водород и oxi(genium) — кислород]ферменты класса оксидоредуктаз (см. оксидоредуктазы), катализирующие включение в молекулу субстрата атома кислорода из О2 с образованием гидроксильной группы (см. гидроксил). Ферментативная реакция протекает при участии окисляющегося при этом восстановленного никотинамидадениндинуклеотидфосфата (НАДФ). Г. локализуются в микросомах и эндоплазматической сети клеток, играют важную роль в обмене ряда циклических соединений, в том числе стероидов. Так, 21-Г. превращает прогестерон в 11-дезоксикортикостерон, а 17-гидроксипрогестерон в 11-дезоксикортизол. Нарушения синтеза Г. в организме вызывает ряд тяжелых заболеваний.Толковый биотехнологический словарь. Русско-английский. > гидроксилазы
См. также в других словарях:
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