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61 Chain, Ernst Boris
SUBJECT AREA: Medical technology[br]b. 19 June 1906 Berlin, Germanyd. 12 August 1979 Ireland[br]Anglo-German biochemist and physiologist, co-worker with Florey in the isolation of sufficient supplies of the antibiotic penicillin for clinical use during wartime.[br]Chain graduated in Berlin at the Charite Hospital in 1930. A refugee from political persecution, in 1933 he went to the School of Biochemistry in Cambridge, and in 1935 moved to the School of Pathology at Oxford. He became a British subject in 1939. His interests had involved the study of enzymes and the isolation of physiologically active substances from natural sources. In 1938 he drew Florey's attention to Fleming's note of 1929 reporting the bacterial growth inhibiting qualities of Penicillium mould. Using makeshift equipment and with little initial support, they isolated small quantities of penicillin, which they were then able to use clinically with dramatic effect.Chain had always hoped for adequate resources to develop penicillin and other antibiotics in Britain. This was not forthcoming, however, and in 1948 a research chair and institute was created for him in Rome, at the International Research Centre for Chemical Microbiology. In 1961 he returned to London to the Chair of Biochemistry at Imperial College. There, with the help of a large donation from the Wolfson Foundation, an appropriate building with facilities for the large-scale development and production of biochemical substances was finally made available. His co-equal part in the development of penicillin was recognized by the sharing of the Nobel Prize for Medicine between Florey, Fleming and himself, and he received numerous honours and honorary degrees from a large number of governments and international institutions.[br]Principal Honours and DistinctionsKnighted 1944. Nobel Prize for Medicine (jointly with H.W.Florey and A.Fleming) 1945. Fellow of the Royal Society 1949. Ehrlich Prize 1954.Bibliography1941, "Penicillin as a chemotherapeutic agent", Lancet (with Florey). 1941, "Further observations on penicillin", Lancet.1949, Antibiotics, Oxford, (with Florey et al.) MG -
62 Guido d'Arezzo
SUBJECT AREA: Recording[br]b. c. 995 Italyd. 1050 Avellana, Italy[br]Italian music theorist who made important developments in musical notation.[br]Guido was originally a monk at the Benedictine Abbey of Pomposa, where he began to introduce innovations into the symbolic representation of music, which greatly helped in the training of choristers. Because of jealousies aroused by this work, he was obliged to leave and settled in Arezzo, capital of the province of that name in northern Italy. Around 1030 he went to Rome at the invitation of the Pope, John XIX, to explain his theories, after which he appears to have settled at the monastery of S.Croce di Fonte, Avellana, where he became prior some three years before his death. In an effort to make it easier for the choristers to maintain correct pitch and to learn the complex polyphonic chants then in development, Guido introduced two major innovations. The first was the use of a four-line staff on which the pitch of successive notes could be recorded. The second was a nomenclature for the first six notes of the major scale supposedly based on the initial syllables of a hymn said to have been composed by him, namely ut (later do), re, mi, fa, so and la. These had a dramatic effect on the learning and singing of music. He also apparently devised forms of parallel voices for plainsong.[br]BibliographyGuido's work is recorded in his treatise, c.1026, Micrologus.Further ReadingWorks describing the development of music and musical notation in medieval times include: W.C.Mickelson, 1977, Hugo Riemann's History of Music Theory, Lincoln: University of Nebraska Press.S.Sadie (ed.), 1980, The New Grove Dictionary of Music and Musicians, vol. 9, London: Macmillan, 803.KF -
63 эффект местной концентрации
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