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41 მოასწავებდა
vaugured, foreboded, foreshadowed, omened, portended, presaged -
42 Abel, John Jacob
SUBJECT AREA: Medical technology[br]b. 19 May 1857 near Cleveland, Ohio, USAd. 26 May 1938 Baltimore, Maryland, USA[br]American pharmacologist and physiologist, proponent of the "artificial kidney" and the isolator of pure insulin.[br]Born of German immigrant farming stock, his early scientific education at the University of Michigan, where he graduated PhB in 1883, suffered from a financially dictated interregnum of three years. In 1884 he moved to Leipzig and worked under Ludwig, moving to Strasbourg where he obtained his MD in 1888. In 1891 he was able to return to the University of Michigan as Lecturer in Materia Medica and Therapeutics, and in 1893 he was offered the first Chair of Pharmacology at Johns Hopkins University, a position he occupied until 1932. He was a pioneer in emphasizing the importance of chemistry, in its widest sense, in medicine and physiology. In his view, "the investigator must associate himself with those who have laboured in fields where molecules and atoms rather than multi-cellular tissues or even unicellular organisms are the units of study".Soon after coming to Baltimore he commenced work on extracts from the adrenal medulla and in 1899 published his work on epinephrine. In later years he developed an "artificial kidney" which could be used to remove diffusible substances from the blood. In 1913 he was able to demonstrate the existence of free amino-acids in the blood and his investigations in this field foreshadowed not only the developments of blood and plasma transfusion but also the possibility of the management of renal failure.From 1917 to 1924 he moved to a study of the hormone content of pituitary extracts, but in 1924 he suddenly transferred his attention to the study of insulin. In 1925 he announced the discovery of pure crystalline hormone. This work at first failed to gain full acceptance, but as late as 1955 the full elucidation of the protein structure of insulin proved the final culmination of his studies.Abel's dedication to laboratory research and his disdain for matters of administration may explain the relative paucity of worldy honours awarded to such an outstanding figure.[br]Principal Honours and DistinctionsFRS.Bibliography1913, "On the removal of diffusible substances from the circulating blood by means of dialysis", Transactions of the Association of American Physiologists.Further Reading1939, Obituary Notices, Fellows of the Royal Society, London: Royal Society.1946, Biographical Memoir: John Jacob Abel. 1857–1938, Washington, DC: National Academy of Sciences.MG -
43 Flechsig, W.
SUBJECT AREA: Electronics and information technology[br]fl. c.1938 Germany[br]German engineer notable for early patents that foreshadowed the development of the shadowmask colour cathode ray tube.[br]In 1938, whilst working for a German electrical company, Flechsig filed a patent in which he described the use of an array of stretched parallel wires to control the landing of either one or three electron beams on separate red, green and blue phosphor stripes within a single cathode ray tube. Whilst the single-beam arrangement required subsidiary deflection to alternate the beam landing angle, the three-beam version effectively used the wires to "mask" the landing of the electron beams so that each one only illuminated the relevant colour phosphor stripes. Although not developed at the time, the concept anticipated the subsequent invention of the shadowmask tube by RCA in the early 1950s and, even more closely, the development of the Sony Trinitron some years later.[br]Bibliography1938, German patent no. 736, 575.1941, French patent no. 866, 065.Further ReadingE.W.Herold, 1976, "A history of colour television displays", Proceedings of the Institute of Electrical and Electronics Engineers 64:1,331.K.G.Freeman, "The history of colour CRTs. A personal view", International Conference on the History of Television, Institution of Electrical Engineers Publication no. 271, p.38.KF -
44 Soane, Sir John
SUBJECT AREA: Architecture and building[br]b. 20 September 1753 Whitchurch, Englandd. 20 January 1837 London, England[br]English architect whose highly personalized architectural style foreshadowed the modern architecture of a century later.[br]Between 1777 and 1780 Soane studied in Italy on a Travelling Scholarship, working in Rome but also making extensive excursions further south to Paestum and Sicily to study the early and more severely simple Greek temples there.His architectural career began in earnest with his appointment as Surveyor to the Bank of England in 1788. He held this post until 1833 and during this time developed his highly individual style, which was based upon a wide range of classical sources extending from early Greek to Byzantine themes. His own work became progressively more linear and austere, his domes and arches shallower and more segmental. During the 1790s and early 1800s Soane redesigned several halls in the Bank, notably the Bank Stock Office, which in 1791 necessitated technological experimentation.The redesigning was required because of security problems which limited window openings to high-level positions and a need for fireproof construction because the site was so restricted. Soane solved the difficulties by introducing light through lunettes set high in the walls and through a Roman-style oculus in the centrally placed shallow dome. He utilized hollow terracotta pots as a lightweight material in the segmental vaulting.Sadly, the majority of Soane's work in the Bank interior was lost in the rebuilding during the 1930s, but Soane went on to develop his architectural style in his houses and churches as well as in a quantity of public buildings in Whitehall and Westminster.[br]Principal Honours and DistinctionsKnighted 1831. Fellow Society of Antiquaries 1795. RA 1802. Royal Academy Professor of Architecture 1806. FRS 1821.Further ReadingSir John Summerson, 1952, Sir John Soane, 1753–1837, Art and Technics. Dorothy Stroud, 1961, The Architecture of Sir John Soane, Studio.DY
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