be+the+subject+of+an+investigation

SUBJECT AREA: Broadcasting, Telecommunications

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After early ambitions to become a professional cricketer, Appleton went to St John's College, Cambridge, where he studied under J.J.Thompson and Ernest Rutherford. His academic career interrupted by the First World War, he served as a captain in the Royal Engineers, carrying out investigations into the propagation and fading of radio signals. After the war he joined the Cavendish Laboratory, Cambridge, as a demonstrator in 1920, and in 1924 he moved to King's College, London, as Wheatstone Professor of Physics.

In the following decade he contributed to developments in valve oscillators (in particular, the "squegging" oscillator, which formed the basis of the first hard-valve time-base) and gained international recognition for research into electromagnetic-wave propagation. His most important contribution was to confirm the existence of a conducting ionospheric layer in the upper atmosphere capable of reflecting radio waves, which had been predicted almost simultaneously by Heaviside and Kennelly in 1902. This he did by persuading the BBC in 1924 to vary the frequency of their Bournemouth transmitter, and he then measured the signal received at Cambridge. By comparing the direct and reflected rays and the daily variation he was able to deduce that the Kennelly- Heaviside (the so-called E-layer) was at a height of about 60 miles (97 km) above the earth and that there was a further layer (the Appleton or F-layer) at about 150 miles (240 km), the latter being an efficient reflector of the shorter radio waves that penetrated the lower layers. During the period 1927–32 and aided by Hartree, he established a magneto-ionic theory to explain the existence of the ionosphere. He was instrumental in obtaining agreement for international co-operation for ionospheric and other measurements in the form of the Second Polar Year (1932–3) and, much later, the International Geophysical Year (1957–8). For all this work, which made it possible to forecast the optimum frequencies for long-distance short-wave communication as a function of the location of transmitter and receiver and of the time of day and year, in 1947 he was awarded the Nobel Prize for Physics.

He returned to Cambridge as Jacksonian Professor of Natural Philosophy in 1939, and with M.F. Barnett he investigated the possible use of radio waves for radio-location of aircraft. In 1939 he became Secretary of the Government Department of Scientific and Industrial Research, a post he held for ten years. During the Second World War he contributed to the development of both radar and the atomic bomb, and subsequently served on government committees concerned with the use of atomic energy (which led to the establishment of Harwell) and with scientific staff.

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SUBJECT AREA: Ports and shipping, Public utilities, Weapons and armour

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The only son of a corn merchant, Alderman William Armstrong, he was educated at private schools in Newcastle and at Bishop Auckland Grammar School. He then became an articled clerk in the office of Armorer Donkin, a solicitor and a friend of his father. During a fishing trip he saw a water-wheel driven by an open stream to work a marble-cutting machine. He felt that its efficiency would be improved by introducing the water to the wheel in a pipe. He developed an interest in hydraulics and in electricity, and became a popular lecturer on these subjects. From 1838 he became friendly with Henry Watson of the High Bridge Works, Newcastle, and for six years he visited the Works almost daily, studying turret clocks, telescopes, papermaking machinery, surveying instruments and other equipment being produced. There he had built his first hydraulic machine, which generated 5 hp when run off the Newcastle town water-mains. He then designed and made a working model of a hydraulic crane, but it created little interest. In 1845, after he had served this rather unconventional apprenticeship at High Bridge Works, he was appointed Secretary of the newly formed Whittle Dene Water Company. The same year he proposed to the town council of Newcastle the conversion of one of the quayside cranes to his hydraulic operation which, if successful, should also be applied to a further four cranes. This was done by the Newcastle Cranage Company at High Bridge Works. In 1847 he gave up law and formed W.G.Armstrong \& Co. to manufacture hydraulic machinery in a works at Elswick. Orders for cranes, hoists, dock gates and bridges were obtained from mines; docks and railways.

Early in the Crimean War, the War Office asked him to design and make submarine mines to blow up ships that were sunk by the Russians to block the entrance to Sevastopol harbour. The mines were never used, but this set him thinking about military affairs and brought him many useful contacts at the War Office. Learning that two eighteen-pounder British guns had silenced a whole Russian battery but were too heavy to move over rough ground, he carried out a thorough investigation and proposed light field guns with rifled barrels to fire elongated lead projectiles rather than cast-iron balls. He delivered his first gun in 1855; it was built of a steel core and wound-iron wire jacket. The barrel was multi-grooved and the gun weighed a quarter of a ton and could fire a 3 lb (1.4 kg) projectile. This was considered too light and was sent back to the factory to be rebored to take a 5 lb (2.3 kg) shot. The gun was a complete success and Armstrong was then asked to design and produce an equally successful eighteen-pounder. In 1859 he was appointed Engineer of Rifled Ordnance and was knighted. However, there was considerable opposition from the notably conservative officers of the Army who resented the intrusion of this civilian engineer in their affairs. In 1862, contracts with the Elswick Ordnance Company were terminated, and the Government rejected breech-loading and went back to muzzle-loading. Armstrong resigned and concentrated on foreign sales, which were successful worldwide.

The search for a suitable proving ground for a 12-ton gun led to an interest in shipbuilding at Elswick from 1868. This necessitated the replacement of an earlier stone bridge with the hydraulically operated Tyne Swing Bridge, which weighed some 1450 tons and allowed a clear passage for shipping. Hydraulic equipment on warships became more complex and increasing quantities of it were made at the Elswick works, which also flourished with the reintroduction of the breech-loader in 1878. In 1884 an open-hearth acid steelworks was added to the Elswick facilities. In 1897 the firm merged with Sir Joseph Whitworth \& Co. to become Sir W.G.Armstrong Whitworth \& Co. After Armstrong's death a further merger with Vickers Ltd formed Vickers Armstrong Ltd.

In 1879 Armstrong took a great interest in Joseph Swan's invention of the incandescent electric light-bulb. He was one of those who formed the Swan Electric Light Company, opening a factory at South Benwell to make the bulbs. At Cragside, his mansion at Roth bury, he installed a water turbine and generator, making it one of the first houses in England to be lit by electricity.

Armstrong was a noted philanthropist, building houses for his workforce, and endowing schools, hospitals and parks. His last act of charity was to purchase Bamburgh Castle, Northumbria, in 1894, intending to turn it into a hospital or a convalescent home, but he did not live long enough to complete the work.

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SUBJECT AREA: Metallurgy

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After graduating in chemistry from the Ecole Polytechnique in 1887, Charpy continued to work there on the physical chemistry of solutions for his doctorate. He joined the Laboratoire d'Artillerie de la Marine in 1892 and began to study the structure and mechanical properties of various steels in relation to their previous heat treatment. His first memoir, on the mechanical properties of steels quenched from various temperatures, was published in 1892 on the advice of Henri Le Chatelier. He joined the Compagnie de Chatillon Commentry Fourchamboult et Decazeville at their steelworks in Imphy in 1898, shortly after the discovery of Invar by G.E. Guillaume. Most of the alloys required for this investigation had been prepared at Imphy, and their laboratories were therefore well equipped with sensitive and refined dilatometric facilities. Charpy and his colleague L.Grenet utilized this technique in many of their earlier investigations, which were largely concerned with the transformation points of steel. He began to study the magnetic characteristics of silicon steels in 1902, shortly after their use as transformer laminations had first been proposed by Hadfield and his colleagues in 1900. Charpy was the first to show that the magnetic hysteresis of these alloys decreased rapidly as their grain size increased.

The first details of Charpy's pendulum impact testing machine were published in 1901, about two years before Izod read his paper to the British Association. As with Izod's machine, the energy of fracture was measured by the retardation of the pendulum. Charpy's test pieces, however, unlike those of Izod, were in the form of centrally notched beams, freely supported at each end against rigid anvils. This arrangement, it was believed, transmitted less energy to the frame of the machine and allowed the energy of fracture to be more accurately measured. In practice, however, the blow of the pendulum in the Charpy test caused visible distortion in the specimen as a whole. Both tests were still widely used in the 1990s.

In 1920 Charpy left Imphy to become Director-General of the Compagnie des Aciéries de la Marine et Homecourt. After his election to the Académie des Sciences in 1918, he came to be associated with Floris Osmond and Henri Le Chatelier as one of the founders of the "French School of Physical Metallurgy". Around the turn of the century he had contributed much to the development of the metallurgical microscope and had helped to introduce the Chatelier thermocouple into the laboratory and to industry. He also popularized the use of platinum-wound resistance furnaces for laboratory purposes. After 1920 his industrial responsibilities increased greatly, although he continued to devote much of his time to teaching at the Ecole Supérieure des Mines in Paris, and at the Ecole Polytechnique. His first book, Leçons de Chimie (1892, Paris), was written at the beginning of his career, in association with H.Gautier. His last, Notions élémentaires de sidérurgie (1946, Paris), with P.Pingault as co-author, was published posthumously.

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SUBJECT AREA: Ports and shipping

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Barlow had little formal academic education, but by his own efforts rectified this deficiency. His contributions to various periodicals ensured that he became recognized as a man of considerable scientific understanding. In 1801, through competitive examination, he became Assistant Mathematics Master at the Royal Military Academy, Woolwich, and some years later was promoted to Professor. He resigned from this post in 1847, but retained full salary in recognition of his many public services.

He is remembered for several notable achievements, and for some experiments designed to overcome problems such as the deviation of compasses in iron ships. Here, he proposed the use of small iron plates designed to overcome other attractions: these were used by both the British and Russian navies. Optical experiments commenced around 1827 and in later years he carried out tests to optimize the size and shape of many parts used in the railways that were spreading throughout Britain and elsewhere at that time.

In 1814 he published mathematical tables of squares, cubes, square roots, cube roots and reciprocals of all integers from 1 to 10,000. This volume was of great value in ship design and other engineering processes where heavy numerical effort is required; it was reprinted many times, the last being in 1965 when it had been all but superseded by the calculator and the computer. In the preface to the original edition, Barlow wrote, "the only motive which prompted me to engage in this unprofitable task was the utility that I conceived might result from my labour… if I have succeeded in facilitating abstruse arithmetical calculations, then I have obtained the object in view."

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SUBJECT AREA: Electronics and information technology

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Boole was the son of a tradesman, from whom he learned the principles of mathematics and optical-component manufacturing. From the early age of 16 he taught in a number of schools in West Yorkshire, and when only 20 he opened his own school in Lincoln. There, at the Mechanical Institute, he avidly read mathematical journals and the works of great mathematicians such as Lagrange, Laplace and Newton and began to tackle a variety of algebraic problems. This led to the publication of a constant stream of original papers in the newly launched Cambridge Mathematical Journal on topics in the fields of algebra and calculus, for which in 1844 he received the Royal Society Medal.

In 1847 he wrote The Mathematical Analysis of Logic, which applied algebraic symbolism to logical forms, whereby the presence or absence of properties could be represented by binary states and combined, just like normal algebraic equations, to derive logical statements about a series of operations. This laid the foundations for the binary logic used in modern computers, which, being based on binary on-off devices, greatly depend on the use of such operations as "and", "nand" ("not and"), "or" and "nor" ("not or"), etc. Although he lacked any formal degree, this revolutionary work led to his appointment in 1849 to the Chair of Mathematics at Queen's College, Cork, where he continued his work on logic and also produce treatises on differential equations and the calculus of finite differences.

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SUBJECT AREA: Medical technology

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After he received his initial education in Scotland, Donald's family moved to South Africa, where he obtained a BA degree in Cape Town in 1930. After the death of his parents he returned to England, graduating in medicine in 1937. He served in the RAF from 1942 to 1946 and was awarded the MBE for bravery in rescuing air-crews. In 1954, following a fruitful period as Reader and Lecturer at St Thomas's Hospital and the Hammersmith Hospital, he was appointed Regius Professor of Midwifery in Glasgow. It was while at St Thomas's and Hammersmith that he evolved a demand-response respirator for infants. With the assistance of Tom Brown, an engineer, and the company Kelvin Hughes—which had earlier produced ultrasound equipment for detecting flaws in metal castings—he was able to originate, develop and improve the diagnostic use of ultra-sound in obstetrics and gynaecology. The use of this technique rapidly spread into other disciplines. Donald was fortunate in that the procedure proved to have no untoward influence on pregnancy; at the time, little was known of possible side effects.

He was the proponent of other advances in the speciality, including laparoscopy, breast-feeding and the preservation of the membranes during labour. An ardent anti-abortionist, his authoritarian Scottish approach made Glasgow a world centre, with himself as a renowned and loved teacher. Despite undergoing three major cardiac interventions, his longevity did not surprise those who knew of his immense vitality.

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SUBJECT AREA: Medical technology

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After studying medicine at a number of schools in Germany, Ehrlich graduated from Leipzig in 1878. After some years at the Charite in Berlin, an attack of tuberculosis compelled a three-year sojourn in Egypt for treatment. Upon his return in 1890, he was invited by Koch to work at the new Institute for Infectious Diseases. There he commenced his work on immunity, having already, while a student, discovered the mast cells in the blood (1877) and then developed the techniques of differential staining which identified the other white cells of the blood. In 1882 he established the diazo reaction in the urine of typhoid patients, and in the same year he identified the acid-fast staining reactions of the tubercle bacillus. He then moved to the study of immunity in infectious disease, which led him to the search for synthetic chemical substances which would act on the causative organism without harming the patient's tissue. The outcome of his specific investigation of syphilis was the discovery of the first two specific chemotherapeutic agents: salvarsan (being the 606th compound to be tested); and the later, but less toxic, neosalvarsan (the 909th). In 1896 he became Director of the State Institute for Serum Research, and in 1906 Director of the new Royal Institute for Experimental Therapy at Frankfurt-am-Main. He received numerous awards and honours from governments and learned societies.

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SUBJECT AREA: Architecture and building, Civil engineering

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As early as 1807 Frost, who was originally a builder and bricklayer in Finchley in north London, was manufacturing Roman Cement, patented by James Parker in 1796, in the Harwich area and a similar cement further south, at Sheerness. In the early 1820s Frost visited Louis J.Vicat (1796–1861) in France. Vicat was a French engineer who began in 1812 a detailed investigation into the properties of various limestones found in France. He later published his conclusions, which were that the best hydraulic lime was that produced from limestone containing clay incorporating silica and alumina. He experimented with adding different clays in varying proportions to slaked lime and calcined the mixture. Benefiting from Vicat's research, Frost obtained a patent in 1822 for what he called British Cement. This patent specified an artificial cement made from limestone and silica, and he calcined chalk with the clay to produce a quick-setting product. This was made at Swanscombe near Northfleet on the south bank of the River Thames. In 1833 the Swanscombe manufactory was purchased by Francis \& White for £3,500 and Frost emigrated to America, setting up practice as a civil engineer in New York. The cement was utilized by Sir Marc Brunel in 1835 in his construction of the Thames Tunnel, and at the same time it was used in building the first all-concrete house at Swanscombe for Mr White.

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SUBJECT AREA: Canals

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Ferdinand de Lesseps was born into a family in the diplomatic service and it was intended that his should be his career also. He was educated at the Lycée Napoléon in Paris. In 1825, aged 20, he was appointed an attaché to the French consulate in Lisbon. In 1828 he went to the Consulate-General in Tunis and in 1831 was posted from there to Egypt, becoming French Consul in Cairo two years later. For his work there during the plague in 1836 he was awarded the Croix de Chevalier in the Légion d'honneur. During this time he became very friendly with Said Mohammed and the friendship was maintained over the years, although there were no expectations then that Said would occupy any great position of authority.

De Lesseps then served in other countries. In 1841 he had thought about a canal from the Mediterranean to the Red Sea, and he brooded over the idea until 1854. In October of that year, having retired from the diplomatic service, he returned to Egypt privately. His friend Said became Viceroy and he readily agreed to the proposal to cut the canal. At first there was great international opposition to the idea, and in 1855 de Lesseps travelled to England to try to raise capital. Work finally started in 1859, but there were further delays following the death of Said Pasha in 1863. The work was completed in 1869 and the canal was formally opened by the Empress Eugenic on 20 November 1869. De Lesseps was fêted in France and awarded the Grand Croix de la Légion d'honneur.

He subsequently promoted the project of the Corinth Canal, but his great ambition in his later years was to construct a canal across the Isthmus of Panama. This idea had been conceived by Spanish adventurers in 1514, but everyone felt the problems and cost would be too great. De Lesseps, riding high in popularity and with his charismatic character, convinced the public of the scheme's feasibility and was able to raise vast sums for the enterprise. He proposed a sea-level canal, which required the excavation of a 350 ft (107 m) cut through terrain; this eventually proved impossible, but work nevertheless started in 1881.

In 1882 de Lesseps became first President d'-Honneur of the Syndicat des Entrepreneurs de Travaux Publics de France and was elected to the Chair of the French Academy in 1884. By 1891 the Panama Canal was in a disastrous financial crisis: a new company was formed, and because of the vast sums expended a financial investigation was made. The report led to de Lesseps, his son and several high-ranking government ministers and officials being charged with bribery and corruption, but de Lesseps was a very sick man and never appeared at the trial. He was never convicted, although others were, and he died soon after, at the age of 89, at his home.

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SUBJECT AREA: Medical technology

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Mackenzie graduated in medicine from Edinburgh University in 1878. The next year he moved to a practice in Burnley, Lancashire, where he began the exhaustive clinical studies into irregularities of cardiac rhythm that he was to continue for the rest of his life. In 1907 he moved to London and in 1913 was appointed physician to the London Hospital.

It was while engaged in the heavy industrial practice in Burnley that he developed, with the aid of a Lancashire watchmaker, the "polygraph" apparatus, which by recording vascular pulses permitted analysis of cardiac function and performance. He also investigated herpes zoster (shingles) and was a pioneer in the treatment of heart disease with digitalis. He himself suffered from angina pectoris for the last fifteen years of his life and his views on the condition were published in a book in 1923. When shown the electrocardiogram (ECG) machine of Einthoven, he expressed reservations as to its future utility.

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SUBJECT AREA: Agricultural and food technology, Chemical technology

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Sustained by the family tanning business in Dole, near the Swiss border, Pasteur's school career was undistinguished, sufficing to gain him entry into the teacher-training college in Paris, the Ecole Normale, There the chemical lectures by the great organic chemist J.B.A.Dumas (1800–84) fired Pasteur's enthusiasm for chemistry which never left him. Pasteur's first research, carried out at the Ecole, was into tartaric acid and resulted in the discovery of its two optically active forms resulting from dissymmetrical forms of their molecules. This led to the development of stereochemistry. Next, an interest in alcoholic fermentation, first as Professor of Chemistry at Lille University in 1854 and then back at the Ecole from 1857, led him to deny the possibility of spontaneous generation of animal life. Doubt had previously been cast on this, but it was Pasteur's classic research that finally established that the putrefaction of broth or the fermentation of sugar could not occur spontaneously in sterile conditions, and could only be caused by airborne micro-organisms. As a result, he introduced pasteurization or brief, moderate heating to kill pathogens in milk, wine and other foods. The suppuration of wounds was regarded as a similar process, leading Lister to apply Pasteur's principles to revolutionize surgery. In 1860, Pasteur himself decided to turn to medical research. His first study again had important industrial implications, for the silk industry was badly affected by diseases of the silkworm. After prolonged and careful investigation, Pasteur found ways of dealing with the two main infections. In 1868, however, he had a stroke, which prevented him from active carrying out experimentation and restricted him to directing research, which actually was more congenial to him. Success with disease in larger animals came slowly. In 1879 he observed that a chicken treated with a weakened culture of chicken-cholera bacillus would not develop symptoms of the disease when treated with an active culture. He compared this result with Jenner's vaccination against smallpox and decided to search for a vaccine against the cattle disease anthrax. In May 1881 he staged a demonstration which clearly showed the success of his new vaccine. Pasteur's next success, finding a vaccine which could protect against and treat rabies, made him world famous, especially after a person was cured in 1885. In recognition of his work, the Pasteur Institute was set up in Paris by public subscription and opened in 1888. Pasteur's genius transcended the boundaries between science, medicine and technology, and his achievements have had significant consequences for all three fields.

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SUBJECT AREA: Canals, Civil engineering

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Pierre Paul Riquet was the son of a wealthy lawyer whose ancestors came from Italy. In his education at the Jesuit College in Béziers he showed obvious natural ability in science and mathematics, but he received no formal engineering training. With his own and his wife's fortunes he was able to purchase a château at Verfeil, near Toulouse. In 1630 he was appointed a collector of the salt tax in Languedoc and in a short time became Lessee General (Fermier Général) of this tax for the whole province. This entailed constant travel through the district, with the result that he became very familiar with this part of the country. He also became involved in military contracting. He acquired a vast fortune out of both activities. At this time he pondered the possibility of building a canal from Toulouse to the Mediterranean beyond Béziers and, after further investigation as to possible water supplies, he wrote to Colbert in Paris on 16 November 1662 advocating the construction of the canal. Although the idea proved acceptable it was not until 27 May 1665 that Riquet was authorized to direct operations, and on 14 October 1666 he was given authority to construct the first part of the canal, from Toulouse to Trebes. Work started on 1 January 1667. By 1669 he had between 7,000 and 8,000 men employed on the work. Unhappily, Riquet died just over six months before the canal was completed, the official opening beingon 15 May 1681.

Although Riquet's fame rightly rests on the Canal du Midi, probably the greatest work of its time in Europe, he was also consulted about and was responsible for other projects. He built an aqueduct on more than 100 arches to lead water into the grounds of the château of his friend the marquis de Castres. The plans for this work, which involved considerable practical difficulties, were finalized in 1670, and water flowed into the château grounds in 1676. Also in 1676, Riquet was commissioned to lead the waters of the river Ourcq into Paris; he drew up plans, but he was too busy to undertake the construction and on his death the work was shelved until Napoleon's time. He was responsible for the creation of the port of Sète on the Mediterranean at the end of the Canal du Midi. He was also consulted on the supply of water to the Palace of Versailles and on a proposed route which later became the Canal de Bourgogne. Riquet was a very remarkable man: when he started the construction of the canal he was well over 60 years old, an age at which most people are retiring, and lived almost to its completion.

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SUBJECT AREA: Chemical technology, Synthetic materials

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Staudinger studied chemistry at the universities of Halle, Darmstadt and Munich, originally as a preparation for botanical studies, but chemistry claimed his full attention. He followed an academic career, with professorships at Karlsruhe in 1908, Zurich in 1912 and Freiberg from 1926 until his retirement in 1951. Staudinger began his work as an organic chemist by following well-established lines of research, but from 1920 he struck out in a new direction. Until that time, rubber and other apparently non-crystalline materials with high molecular weight were supposed to consist of a disordered collection of small molecules. Staudinger investigated the structure of rubber and realized that it was made up of very large molecules with many basic groups of atoms held together by normal chemical bonds. Substances formed in this way are known as "polymers". Staudinger's views first met with opposition, but he developed methods of determining the molecular weights of these "high polymers". Finally, the introduction of X-ray crystallographic investigation of chemical structure confirmed his views. This discovery has proved to be the basis of a new branch of chemistry with momentous consequences for industry. From it stemmed the synthetic rubber, plastics, fibres, adhesives and other industries, with all their multifarious applications in everyday life. The Staudinger equation, linking viscosity with molecular weight, is still widely used, albeit with some reservations, in the polymer industry.

During the 1930s, Staudinger turned his attention to biopolymers and foresaw the discovery some twenty years later that these macromolecules were the building blocks of life. In 1953 he belatedly received the Nobel Prize in Chemistry.

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SUBJECT AREA: Medical technology

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He qualified at St Bartholomew's Hospital in 1938 and after early hospital posts served in the Army as a specialist in pathology in West Africa and Singapore. In 1947 he joined the Medical Research Council (MRC) and until 1957 he was involved with the Pneumoconiosis Research Unit in investigation of dust inhalation. In 1957 he transferred to the National Institute for Medical Research, to concentrate on instrument development, and in 1969 to the Bioengineering Division of the MRC Clinical Research Centre at Northwick Park Hospital. He was responsible for a number of instrumental developments and inventions in the fields, amongst others, of respiration measurement, blood alcohol levels and variable adjustable spectacle lenses (achieved by altering the curvature of the surface of a thinwalled transparent fluid cell).

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SUBJECT AREA: Aerospace, Electronics and information technology

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After secondary education at King Edward School, Birmingham, Boot studied physics at Birmingham University, obtaining his BSc in 1938 and PhD in 1941. With the outbreak of the Second World War, he became involved with Randall and others in the development of a source of microwave power suitable for use in radar transmitters. Following unsuccessful attempts to use klystrons, they turned to investigation of the magnetron, and by adding cavity resonators they obtained useful power on 21 February 1940 at a wavelength of 9.8 cm. By May a cavity magnetron radar system had been constructed at TRE, Swanage, and in September submarine periscopes were detected at a range of 7 miles (11 km).

In 1943 the physics department at Birmingham resumed its research in atomic physics and Boot moved to BTH at Rugby to continue development of magnetrons, but in 1945 he returned to Birmingham as Nuffield Research Fellow and helped construct the cyclotron there. Three years later he took up a post as a Principal Scientific Officer (PSO) at the Services Electronic Research Laboratories at Baldock, Hertfordshire, becoming a Senior PSO in 1954. He remained there until his retirement in 1977, variously carrying out research on microwaves, magnetrons, plasma physics and lasers.

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SUBJECT AREA: Medical technology

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Cannon graduated with an arts degree from Harvard University in 1896. He then became a medical student and carried out an investigation into stomach movements using the technique of radio-opaque meals, initially in a cat. He qualified in medicine from Harvard in 1900 and was soon appointed Assistant Professor of Physiology. In 1906 he succeeded to the Chair of Physiology, which he held for thirty-six years.

Apart from his early work, Cannon's demonstration of the humoral transmission of the nerve impulse was fundamental, as were his investigations, including researches on himself and his colleagues, into the relationship between emotion and the sympathetic-adrenal system.

During the First World War he served with both the British and American armies and was decorated.

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SUBJECT AREA: Medical technology

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Forsmann studied medicine at the University of Berlin, graduating in 1929. He later became chief of the surgical clinic in Dresden-Friedrichstadt, and in 1958 he became head of the surgical division of the Evangelical Hospital in Düsseldorf.

Intravascular catheterization had been undertaken in research with animals by Marey in 1861, and had been used in 1912 by Unger et al. in the treatment of puerperal sepsis. In 1929 Forsmann inserted a catheter into his own cubital vein and up into the heart, monitoring its position with X-rays. Continuing experiments demonstrated that it was possible to undertake radiographic studies of the heart using contrast media. Despite the outstanding potential of the technique, its immediate adoption was held to present unacceptable dangers; it was not until developments in anaesthesia and antibiotics that the technique achieved its present position as a routine investigation permitting the widespread practice of angiocardiography. Deterred by criticism, Forsmann turned his energies to urology, gaining much distinction in this field.

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SUBJECT AREA: Electricity

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Joubert became Professor of Physics in the Collège Rollin, Paris, in 1874, a position he held until 1888. He was at one time General Secretary of the Société Française de Physique. In collaboration with Pasteur he began studies into the theories of germs and bacteria. In 1880 Joubert carried out research on wave-forms in alternating-current arc-lighting circuits. Reinventing a method previously used by earlier experimenters, including Wheatstone, he was, by a mechanical sampling technique, able to determine the voltage at different points in the cycle. By using a rotating contact on the alternator shaft, the angular position of which could be varied, the whole of the wave-form could be delineated. This successful technique was widely used for some thirty years.

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See also: Duddell, William du Bois

SUBJECT AREA: Medical technology

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The seventh and youngest son of a baker, after entering Edinburgh University at the tender age of 14 he graduated in 1832 and when only 28 was appointed Professor of Midwifery at Edinburgh University. Following the introduction of ether as a general anaesthetic (see W.T.G.Morton) he was the first to use it in midwifery. Aware of its disadvantages, he experimented on himself, and on 4 November 1847 he discovered the anaesthetic properties of chloroform. However, there were both medical and religious objections to its use, until in 1853 it was administered to Queen Victoria at the birth of Prince Leopold.

Widely recognized as a great obstetrician, he also founded the modern practice of gynaecology, introducing new diagnostic methods and techniques of investigation. He was also an enthusiastic archaeologist.

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SUBJECT AREA: Public utilities

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Son of an Army surgeon-general, he graduated in Edinburgh in 1889. Specializing in public health and forensic matters, he worked from 1897 to 1905 for the Local Government Board on lead poisoning resulting from moorland water supplies. He also acted as Bacteriologist to the Royal Commission on Sewage Disposal from 1890 to 1905. In 1905 he was appointed Director of Water Examinations to the Metropolitan Water Board, with whom he served until his death. Shortly before he joined the Board, he was involved in the investigation of an outbreak of typhoid at Lincoln and was instrumental in establishing a chlorination plant of a rudimentary nature there, and also in organizing the comprehensive chlorinating system which was then applied to London's water supply. He also advised on water supplies in Egypt and Canada.

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