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1 prontosil
• prontosil; vrsta baktericida iz grupe sul -
2 prontosil
nCHEM prontosil m -
3 prontosil
мед.сущ. пронтозил -
4 prontosil
n. 프론토실(화농성 세균에 의한 병의 트효약) -
5 prontosil
புரந்தசில் -
6 Domagk, Gerhard Johannes Paul
SUBJECT AREA: Medical technology[br]b. 30 October 1895 Lagow, Brandenburg, Germanyd. 24 April 1964 Burgberg, Germany[br]German physician, biochemist and pharmacologist, pioneer of antibacterial chemotherapy.[br]Domagk's studies in medicine were interrupted by the outbreak of the First World War and his service in the Army, delaying his qualification at Kiel until 1921. For a short while he worked at the University of Greifswald, but in 1925 he was appointed Reader in Pathology at the University of Munster, where he remained as Extraordinary Professor of General Pathology and Pathological Anatomy (1928) and Professor (1958).In 1924 he published a paper on the role of the reticulo-endothelial system against infection. This led to his appointment as Director of Research by IG Farbenindustrie in their laboratory for experimental pathology and bacteriology. The planned programme of research into potential antibacterial chemotherapeutic drugs led, via the discovery of the dye Prontosil rubrum by his colleagues, to his reporting in 1936 the clinical antistreptococcal effects of the sulphonamide drugs. These results were confirmed in other countries, but owing to problems with the Nazi authorities he was unable to receive until 1947 the Nobel Prize that he was awarded in 1939.Domagk turned his interest to the chemotherapy of tuberculosis, and in 1946 he was able to report the therapeutic activity of the thiosemicarbazones, which, although too toxic for general use, in their turn led to the discovery of the potent and effective isoniazid. In his later years he moved into the field of cancer chemotherapy, but interestingly he wrote, "One should not have too great expectations of the future of cytostatic agents." His only daughter was one of the first patients to have a severe streptococcal infection successfully treated with Prontosil rubrum.[br]Principal Honours and DistinctionsNobel Prize for Medicine 1939. Foreign Member of the Royal Society. Paul Ehrlich Gold Medal.Bibliography1935, "Ein Beitrag zur Chemotherapie der bakteriellen Infektionen", Deutsche med. Woch.1924, Virchows Archiv für Path. Anat. und Physiol. u.f. klin. Med. 253:294–638.Further Reading1964, Biographical Memoirs of the Royal Society: Gerhard Domagk, London.MGBiographical history of technology > Domagk, Gerhard Johannes Paul
См. также в других словарях:
Prontosil — chlorhydrate de prontosil Général Nom IUPAC 4 (2,4 diaminophényl) diazénylbenzènesulfonamide … Wikipédia en Français
Prontosil — Saltar a navegación, búsqueda Imagen en 3D de la molécula del Prontosil (Sulfamidocrisoidina) El Prontosil fue el primer fármaco de síntesis con acción bactericida amplia. Su número CAS de registro es 103 12 8. Su nombre químico es p ((2,4… … Wikipedia Español
Prontosil — drugbox IUPAC name = 4 [(2,4 diaminophenyl)azo] benzenesulfonamide CAS number = 103 12 8 ATC prefix = ATC suffix = ATC supplemental = PubChem = 66895 DrugBank = C=12 | H=13 | N=5 | O=2 | S=1 molecular weight = 291.33 g/mol bioavailability =… … Wikipedia
Prontosil — The first sulfa drug to be discovered. Largely of historic interest today. The discovery was made by the great German physician and chemist Gerhard Domagk (1895 1964). In 1925 Domagk was named Lecturer in Pathologic Anatomy (pathology) in the… … Medical dictionary
Prontosil — ▪ drug also called sulfamidochrysoidine trade name of the first synthetic drug used in the treatment of general bacterial infections in humans. Prontosil was introduced into medicine in the 1930s. Prontosil resulted from research,… … Universalium
Prontosil — Strukturformel Allgemeines Name Sulfamidochrysoidin Andere Namen 4 (2,4 Diaminophenyl) diazenylbenzensulfonamid … Deutsch Wikipedia
prontosil — ˈpräntəˌsil noun ( s) Etymology: German : any of three sulfonamide drugs: a. or prontosil rubrum : a red azo dye H2NSO2C6H4N . NC6H3(NH2) … Useful english dictionary
prontosil rubrum — prontosil ru·brum rü brəm n PRONTOSIL (a) … Medical dictionary
prontosil album — prontosil al·bum al bəm n SULFANILAMIDE … Medical dictionary
prontosil soluble — n AZOSULFAMIDE … Medical dictionary
prontosil album — noun see prontosil … Useful english dictionary